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Frequently, the increase in cathepsin expression and activity correlated with malignant progression and metastasis possibly by direct degradation of the extracellular matrix or by activation of other proteases such as the urokinase-type plasminogen activator (Turk et al, 2000).
Cathepsin B influences tumor microenvironment by degradation of extracellular matrix and by activation of other proteolytic enzymes such as pro-urokinase-type plasminogen activator (pro-uPA) and matrix metalloproteases (MMPs) so that tumor cells can actively invade and metastasize[45].
It is possible that the absence or reduction of each PTP can be compensated by activation of other two PTPs after UVB irradiation.
Second, insufficient recruitment of particular areas may be compensated by activation of other brain regions.
Since Takayanagi et al. suggested that NFATc1 is the master regulator of RANKL-induced osteoclastogenesis [ 5], this is the first report that suppression of NFATc1 can be overcome by activation of other signal pathways.
Increased levels of antigen-antibody immune-complexes lead to deposition of these in various tissues, causing inflammation and damage by activation of other immune pathways, for example, the complement system.
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For example in the prion disease model, PERK activation does not seem to be accompanied by activation of the other two UPR branches, which makes it a very specific type of PERK activation, possibly not via ER stress [ 65, 72].
While in previous studies the interplay is mainly characterized by activation of each other's ligands, in our study we provide evidence that antagonists may also play a central role in the crosstalk.
Third, the inhibition obtained by these agents is counterbalanced by the activation of other parallel pathways that signal downstream of the inhibition.
It is therefore very likely that tumorogenesis in Ubc9 mutants is supported not only by loss of Dap/p21 but also by the activation of other oncogenic and pro-inflammatory proteins (Fig. 7).
The tapping behavior was segregated out from feeding behavior by the flip-out Gal80 technique, suggesting that the former is induced by the activation of other cell(s) expressed in the same line.
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by activation of second
by activation of alternative
by activation of postsynaptic
by evidence of other
by activation of cell-survival
by inactivation of other
by activation of endogenous
by abandonment of other
by activation of multiple
by virtue of other
by activation of lexical
by permission of other
by substitution of other
by activation of uninfected
by activation of nuclear
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