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FGFs elicit activity by activation of an oligomeric complex of transmembrane receptor tyrosine kinases and HS proteoglycans.
JNK was activated by microinjection of Mos, by activation of an estrogen-inducible form of Raf, and by a constitutively active MEK-1 (MEK R4F), indicating that the p42 MAPK cascade can trigger JNK activation.
Verma, D. et al. Hunger promotes fear extinction by activation of an amygdala microcircuit.
Vache, C. et al. Usher syndrome type 2 caused by activation of an USH2A pseudoexon: implications for diagnosis and therapy.
Indeed, dCGN induced NF-κB activation as shown by degradation of IκBα, translocation of p65 and p50 sub-units to the nucleus and by activation of an NF-κB-responsive luciferase reporter plasmid.
Many of the 469 candidate STEPs not reported to have EST evidence of alternative splicing may exhibit an effect leading to an upstream transcript start (where an upstream exon is added by activation of an upstream splice site), intron extension (by activation of a weaker splice site in the adjacent exon) or exon skipping.
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Harvey, C. D. et al. The spread of Ras activity triggered by activation of a single dendritic spine.
Apoptosis is an active gene-directed death process mediated by activation of a number of cysteine proteases; therefore, it may be preventable with selective inhibitors.
Recent genetic characterization of another APC/C component, APC8, has linked APC activities to the transcriptional repression of CycB1 1 by activation of a repressor of DUO POLLEN 1, miR159 [ 51].
Engagement of TLRs to their appropriate ligands is followed by activation of a specific sequence of protein tyrosine kinases, mitogen-activated protein kinases and extracellular-activated receptor kinase molecules.
Laureti, L. et al. Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.
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