Sentence examples for by activating gene expression from inspiring English sources

Moreover, [Ca2+] i transients trigger activity-dependent developmental events in neurons, by activating gene expression, cytoskeletal elements, or neurotransmitter release, whereas the characteristics of these responses are determined by amplitude, frequency, source, and spatial location of Ca2+ signals (for review, see Moody and Bosma 2005).

HDAC inhibitors (HDACi) such as vorinostat, also known as suberoylanilide hydroxamic acid (SAHA), flush HIV out from reservoirs of latently infected cells by activating gene expression in proviruses [11, 12].

They play central roles in response to several stresses by activating gene expression via the stress response element (STRE) (reviewed in [ 13, 7]).

The nucleus, because of its mechanical properties and interconnections with the cytoskeleton, can act as a mechanosensor of internal and external forces, converting these signals into biological responses by activating gene expression (52, 53).

PKC activation increases the expression of transforming growth factor-β (TGF-β), which is one of the most important growth factor regulating extracellular matrix production by activating gene expression of proteoglycans and collagen and decreasing the synthesis of proteolytic enzymes that degrade matrix proteins [ 54].

Thus, even though the WDR5 F266A mutation can bind the full MLL complex and does not affect catalytic activity, the inability to bind lncRNAs strongly compromises WDR5 function in activating gene expression by reporter gene assay.

In most cases, AR usually triggers its action by binding to testosterone and activating gene expression following nuclear translocation.

Both systems respond in opposite ways to the presence of tetracyclines (e.g. doxycycline, Dox), by either inactivating (Tet-Off) or activating gene expression (Tet-On).

Similarly, in gain-of-function experiments, the telo box is not able by itself to activate gene expression in transgenic plants but acts in synergy with other cis-acting elements like site II motifs or TEF boxes [ 11, 12].

Rap1p is an abundant nuclear protein of 827 amino acids that was first discovered by its ability to repress or activate gene expression (repressor activator protein 1) (Shore and Nasmyth 1987).

STAT1 now activated, oligomerises, is further phosphorylated by PRKCD [ 30] and translocates to the nucleus where it directly activates gene expression by binding to STAT sites present in the promoters of numerous genes.