This rapid extension growth is based on cell elongation and accelerated cell division, which is attended by the consumption of energy and solutes[26].
We concluded that most demethylation events are likely due to "passive demethylation" preferentially in late-replicating regions following accelerated cell division during malignant transformation caused by genomic and transcriptome changes, although some loss of methylation including that in the IGF2BP3 promoter could be related to tumor progression.
The accelerated cell division of undifferentiated E/M cells might be supported by the high production of extracellular matrix proteins, observed in early passages (Figure 3C), whereas low cell densities of E/M-MP cells, or growth among more differentiated cells, enforces differentiation and the rapid loss of CD133 (Figures 7A,B).
We found that increasing AurkC level in one blastomere of the 2-cell embryo accelerated cell division and decreasing AurkC level slowed down mitosis.
These results show that the rate of telomere loss changes during ontogeny, suggesting the existence of periods of accelerated cell division.
Dozens of studies confirm that IGF-1, which accelerates cell division, substantially increases the risk of breast, prostate, colon, lung, and other cancers.
However, the identification by Ewing et al. of novel retrocopies in tumours is consistent with retrotransposition taking place under conditions of accelerated cell division.
The only statistically significant effect of flurbiprofen was to accelerate cell division in the rat colonic tumours.
Sepal primordia had accelerated cell division, cell enlargement, anisotropic growth, and decoupling of DNA synthesis from cell volume, with a concomitant increase in cell size heterogeneity.
The functional composite cyclin D1/CDK4 can induce cell cycle transition from G1 to S phase, initiate synthesis and replication of DNA, and accelerate cell division.
