Sentence examples for by abnormal expression of from inspiring English sources

Like other genetic disorders, RS is characterized by abnormal expression of a gene, resulting in a clinical phenotype.

In spite of CIN caused by abnormal expression of Nlp in cell models, the deregulated expression and genetic alterations of Nlp in human tumours remain unclear.

Interestingly, transcriptomic classification revealed that these tumours belong to the group of patients with specific features: younger female patients frequently coming from Africa or Asia with tumours characterised by abnormal expression of oncofetal genes (EPCAM, AFP and KRT19).

These results are consistent with previous results showing that ILDR1 affects the recruitment and localization of tricellulin to tricellular junctions in epithelial cells (Higashi et al., 2013) and suggest that profound hearing loss by ILDR1 deficiency might be partly explained by abnormal expression of tricellulin.

The main mechanism of the microRNoma (a term we coined for the full complement of miRNAs present in a genome) alteration in cancer cells is represented by aberrant gene expression, characterized by abnormal expression of mature and/or precursor miRNA sequences in comparison with corresponding normal tissues.

Recently, we reported that low 2-ME plasma concentrations at 11 14 weeks of gestation are associated with the development of preeclampsia, but these low concentrations cannot be explained by abnormal expression of COMT [ 11], and there are conflicting results regarding the presence of SNPs that could reduce the activity of COMT in patients with PE.

Aberrant expression of miRNAs in cancer is characterized by abnormal expression levels of mature or precursor miRNA transcripts in comparison with those in the corresponding normal tissues.

We sought to determine whether the anomalous neuronal patterning seen in GD18 foetal forebrains after maternal injections of LPS at GD15 and GD16 was accompanied by abnormal expression levels of IEGs.

Here we showed that adherens junction loss in pRb-null osteoblasts is accompanied by abnormal expression patterns of OB- and N-cadherins, which are the predominant osteoblasts cadherins.

These new methods may provide a clearer picture of the difference between the structure of genes that are "on" and genes that are "off". As many cancers are driven by the abnormal expression of genes such as oncogenes and tumor suppressors, information about how DNA structure can turn genes on and off may aid in the development of cancer therapies.

Therefore, we reasoned that the atypical susceptibility of mDCs-rtv to NK lysis might be caused by an abnormal expression of NK activatory receptors on their surface.