Sentence examples for by abnormal activation of from inspiring English sources
Autoimmune diseases may be initiated by malfunctioning lymphocytes whose apoptotic pathways, normally activated by self-antigens, are blocked by abnormal activation of NF-κB, enabling the survival of self-reactive cells [ 21, 127- 130].
Next, we investigated whether the characteristics of CSLCs in tumorspheres were maintained by abnormal activation of the SHH pathway.
This effect is likely triggered in part by abnormal activation of liver endothelial cells as suggested by Yan et al and Wu et al [23], [41].
These symptoms may be mediated by abnormal activation of the Renin-Angiotensin-Aldosterone System (RAAS), as well as of endothelin.
This suggests that enhanced seizure susceptibility in the Fmr1 KO mouse is at least partially mediated by abnormal activation of mGluR5-dependent signal transduction which is largely suppressed in WT mice.
12– 17 Therefore, insufficient HAI-1 function on the epithelial cell surface may result in deregulated pericellular proteolysis followed by abnormal activation of bioactive molecules and subsequent downstream signaling, which eventually accelerates malignancy progression.
Figure 5 demonstrates that the suppressive effect of mature α/β TCR transgenes on DN cell proliferation is mediated by the abnormal activation of PKD2 catalytic activity.
Further experiments suggested that the reaction was caused by the abnormal activation of certain genes in the iPS cells, resulting in the production of proteins that seemed foreign to the immune systems of the mice.
This possible mechanism was explained therein according to an excessive sympathetic reaction, causing an opposite reaction to the initiated by an abnormal activation of mechanoreceptors activation, and also causing the activation of the afferent vagal fibers.
Currently, no ideal treatment for ALCL caused by the abnormal activation of ALK and its downstream signaling pathways is available.
TTP is caused by a hereditary (genetic) or acquired (autoantibodies) ADAMTS13 deficiency, whereas aHUS is caused by an abnormal activation of the alternative complement pathway due to defective regulation of specific complement factors [ 50, 61– 63].
