The loss of SDC-1 at the cell-surface could also occur through a switch to translation of alternative, non-membranous isoforms, or by aberrant processing in an advanced tumor.
Since mismatches in the genome would most likely be repaired by host enzymes before integration, we speculate that the transversion was produced by base misincorporation during gap filling or aberrant processing of the unpaired nucleotides at the viral 5' end, followed by mismatch repair that fixed the mutation (Fig. 1B).
Thus, the defect in error-free DDT attributed to replication checkpoint deficiency is largely due to aberrant processing of SCJs by the prematurely activated Mus81-Mms4 (see Figure 5).
Moreover, these results, in combination with clinicopathological investigations of epidermal diseases derived from the aberrant processing of profilaggrin by SASPase mutation, will provide a novel concept to dissect the complex mechanisms of percutaneous antigen priming in atopic diseases.
Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism.
For example, insertion of TE elements might introduce functional splice and poly-adenylation sites [ 25- 29], resulting in aberrant processing of some of the transcripts produced by a gene.
In sum, a valid, but inconvenient interpretation of AD genetics is that the aberrant processing of APP, or of other proteins cleaved by presenilin containing enzymes, is the key contributing factor in familial AD, rather than solely aberrant production of Aβ that contributes to histopathology.
Aberrant processing of APP would result in excessive Aβ generation and the process is known to be modulated by a number of APP-interacting proteins including FE65.
Myotonic dystrophy is caused by nucleotide repeat expansions in the non-coding region of specific mRNAs, which act to sequester splicing factors such as the muscle blind protein away from the pre-mRNA processing machinery leading to aberrant processing of distinct target mRNAs in different tissues [57].
In one case with a mutation of the precursor, we observed aberrant processing of the miR-142-5p miR-142-5p miR-142-5p
