OA pain is caused by aberrant functioning of a pathologically altered nervous system with key mechanistic drivers from peripheral nerves and central pain pathways.
Today, new insights in the structural and functional characteristics of the endometrium and myometrial junctional zone (the "endomyometrium"), in women with adenomyosis and endometriosis, provide increasing evidence that they are frequently associated and both are characterized by an aberrant function of the endomyometrium.
These data, and the fact that PBMCs from one-third of SLE patients did not produce IFN-α, suggest that the observed decrease in IFN-α production is caused by aberrant function in SLE pDCs or depletion of some proportion of pDCs, and not by a decrease in total pDC count.
The ras pathway is activated by a variety of extracellullar factors, and aberrant function of ras signal transduction is not only due to ras mutations.
Aberrant function of p53 proteins is a frequent mechanism by which its inhibitory role in tumorigenesis is weakened, both in sporadic cancers, which often develop mutations of p53, and in individuals who inherit germline mutations.
Inactivating mutations of the PRKAR1A gene lead to aberrant function of PKA and increased phosphorylation of targets implicated in cell transcription, metabolism, cell cycle progression and apoptosis [9].
Immunohistochemistry staining of p53 is a cheap and simple method to detect aberrant function of p53.
In this model, we have correlated these phenomena to the aberrant function of intracellular ASYN.
Thus, aberrant function of the pathways involved might result in chemoresistance.
Postural sway is a sensitive test of the integrity of motor control that is likely to be affected by abnormal or aberrant functioning of the cerebellum, basal ganglia, and brainstem.
