Sentence examples for by aberrant expression of from inspiring English sources

Downregulation of MICA/MICB in these cancer cells is mediated by aberrant expression of an oncogenic microRNA, miR20a76.

Mantle cell lymphoma (MCL) is a malignancy of mature B cells characterized by aberrant expression of cyclin D1 due to the translocation t(11 14).

Analysis of the gene failed to identify tumor-specific promoter methylation or coding region mutations, suggesting that NOL7 loss may be mediated by aberrant expression of its upstream regulators.

Apoptosis can be induced by aberrant expression of certain oncogenes, such as c-Myc and E2F1, which may act as a "fail-safe" mechanism to eradicate potential cellular transformation [33], [50].

We demonstrate that disruption of Dazl results in a post-migratory, pre-meiotic reduction in PGC number accompanied by aberrant expression of pluripotency genes and failure to erase and re-establish genomic imprints in isolated male and female PGCs, as well as subsequent defect in progression through meiosis.

We note that tissue specimens that were deemed to be MUC1-negative cancers showed normal apical staining with both MUC1 antibodies in regions outside of the margin of malignancy (data not shown) confirming that the assay was correctly performed but that these cancers were not characterized by aberrant expression of MUC1.

It has been shown that in 90% of GBMs RTK signaling is dysregulated, either by aberrant expression or mutations of the receptors themselves or of their downstream effectors.

The antiproliferative response of tumor cells to TGF-β can also be affected by aberrant expression or inactivation of cell cycle regulators that function downstream of or independently of the TGF-β/SMAD pathway.

We show that cystinotic cells are characterized by aberrant expression and localization of the CMA receptor LAMP2A, which results in defective lysosomal degradation of CMA substrates in cystinotic mice.

This process is sustained by the aberrant expression of BAFF by B lymphocytes infiltrating the SGs [ 86, 87].

Breast cancer is a heterogenous disease whose progression from atypical ductal hyperplasia (ADH) to ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) is regulated by the aberrant expression of multiple mediators produced by the mammary tumor itself and the adjacent reactive stroma [ 1].