Sentence examples for by aberrant activation of from inspiring English sources
It was reported that constitutive nuclear NF- κB activity in two chemoresistant lymphoma cell lines was caused by aberrant activation of IKK's and overexpression of defective I κB α (Krappmann et al, 1999).
Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF-κB.
Organ-specific autoimmune diseases, such as psoriasis, rheumatoid arthritis, multiple sclerosis and autoimmune diabetes, are initiated by aberrant activation of interferon-γ (IFN-γ -producing T helper 1 (Th1) cells that recognIFN-γ -producings expressed IFN-γ -producingans.
Tyrosine phosphorylation events mediated by aberrant activation of Receptor Tyrosine Kinase (RTK) pathways have been proven to be involved in the development of several diseases including cancer.
One subgroup was characterised by aberrant activation of the WNT/ β-catenin pathway.
Cancer is in part driven by aberrant activation of growth-promoting oncogenes.
The depletion of transcripts of five genes by siRNA led to lethality only in a cellular context characterized by the aberrant activation of the Wnt/β − catenin signaling pathway due to a CTNNB1 activating mutation.
By integrating these pathways with a number of dysregulated networks of TFs (eg, SRF, MYC, E2F1, CREB1, LEF1, TCF7, HNF1B/HNF1A and HNF4A), they suggested that epithelial dedifferentiation accompanied by aberrant activation and cross talk of specific signaling pathways may be required for PKD1 cyst growth and disease progression.
Oncogene-induced senescence is a program initiated by the aberrant activation of oncogenes.
In aging, the progerin splice variant is produced by the aberrant activation of various cryptic splice sites naturally present within the LMNA gene.
The increase in p27kip1 and p57kip2 levels (figure 5D) resulting from Notch inhibition could not overcome the unrestricted proliferation induced by the aberrant activation of Wnt/β-catenin signalling.
