Sentence examples for by a viral vector from inspiring English sources

The goal of these experiments was to test a modified design of the cochlear implant electrode that includes a coating of fibroblast cells transduced by a viral vector with a BDNF gene insert.

These studies collectively suggest that more work is needed before a DNA approach alone or a DNA prime followed by a viral vector boost is able to completely control the pathogenic challenge in these model systems.

In addition, our finding that the Ad5-specific cytokine profile is present prior to vaccination indicates that the type of response induced by a viral vector vaccine may be pre-determined by a vaccine recipient's memory repertoire defined by natural exposures and inherited HLA haplotype.

The ability to purify recombinant proteins from infiltrated tissue rather than tissue systemically infected by a viral vector is expected allow larger proteins to be reliably expressed from TMV vectors without concerns about insert stability in the virus.

Therapeutic use of CFH delivered by 2-weekly intravenous injection of fresh frozen plasma (half-life 6 days) (46) is not practicable on the necessary scale, but local delivery of an inducible recombinant CFH to the choroid or retinal pigment epithelium by a viral vector may be more achievable (47, 48).

Early studies have revealed that the potency of the T-cell responses was enhanced when an initial immunization with plasmid DNA was followed by a viral vector, both encoding the same antigen in a so-called heterologous prime-boost regimen in that it was more potent than either the DNA or viral vector alone, independently of the order of administration (Schneider et al, 1998).

Although it's possible to deliver CRISPR's components into cells in a dish as proteins or RNA, so far researchers can usually only get it working in tissue inside the body by using a viral vector to deliver the DNA for Cas9 into cells.

They can be transformed into organisms in the form of plasmids or in the appropriate format, by using a viral vector.

To investigate the role of the CDK5 signaling pathway in the differentiation of NPCs, we studied the effects of activating this pathway in the adult rat hippocampal NPC model by utilizing a viral vector expressing the CDK5 activator, p35.

To elucidate if glutathione depletion causes selective degeneration of nigral dopaminergic neurons, we down-regulated glutathione synthesis in different brain areas of adult rats by a viral vector-based RNAi approach.

We have developed a novel method to selectively suppress retino-tectal synaptic transmission, both in vitro and in vivo, by photo-activating eNpHR expressed in RGC axons by means of a viral vector.