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The plasma concentrations of PAS were measured by a validated liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) method.
Levels of XR5944.14 were measured by a validated liquid chromatography tandem mass spectrometry at Huntingdon Life Sciences, Cambridgeshire.
TDM samples were determined in whole blood by a validated liquid chromatography-mass spectrometric method in two laboratories or by FPIA Abbott Laboratoriess, Abbott Park, IL).
Plasma concentrations of ZK 219477 were determined by a validated liquid chromatography mass spectrometry method using C4-ZK 219477 as internal standard.
Quantification of macitentan, ACT-132577, and ACT-373898 in plasma was performed by a validated liquid chromatography with tandem mass spectrometry (LCMS/MS) method.
Ifosfamide and the 2-dechloroethyl and 3-dechloroethyl metabolites were simultaneously quantitated by a validated liquid chromatography tandem triple quadrupole mass spectrometry (LC-MS/MS) assay.
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The concentration of 1-hydroxymidazolam was determined by using a validated liquid chromatography coupled with tandem mass spectrometry detection (LC-MS/MS) method.
The plasma and effluent concentrations of ciprofloxacin (molecular weight (MW) 331.3), meropenem (MW 383.5), piperacillin (MW 517.6), and tazobactam (MW 300.3) were determined by using a validated liquid chromatography with tandem mass spectrometry method that has been described previously [ 9]; see online supplement (Additional file 1) for more details.
Pharmacokinetic analysis for sorafenib was done by Bayer HealthCare Pharmaceuticals using a validated liquid chromatography mass spectrometry method (Moore et al, 2005).
Pharmacokinetic measurements of EP-101 were performed by Simbec Research Limited (Merthyr Tydfil, UK) using a validated liquid chromatography-tandem mass spectrometry (LC-MS-MS) method 10.
Plasma and urine apremilast, CC-10007 (R-enantiomer of apremilast) and CC-10055 (M7) concentrations were measured using a validated liquid chromatography-mass spectrometry method conducted and validated by QPS, LLC (Newark, DE, USA).
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by a thick liquid
by a separate liquid
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