Each possible combination of mutation counts is a unique mutational configuration.
One rectal cancer (of a patient hereafter referred to as Patient 1) stood out from this series because of a unique mutational pattern characterized by microsatellite instability (MSI+) and nine somatic alterations, eight in APC and one in CTNNB1 (Table 1).
Thus, not only the mutation rate increase conferred by a mutator allele, but also its unique mutational signature (i.e., preferred type of mutation and bias to a genomic context, if any) generates its effect on genome stability and evolution.
Haplotypes within these regions can be represented by a unique gene tree that describes their mutational history.
The unique mutational profile of GATA3, dominated by frameshift mutations, may prompt further investigations about their mechanism of onset and significance.
Finally, forking chains of immediate inclusions of regular marker sets growing from the root form a unique strict mutational compatibility consensus (SMCC) tree.
In a comparison to two domestic chicken genomes and the Gallus gallus reference genome, we found no unique mutational processes shaping the DT40 genome except for a mild increase in insertion and deletion events, particularly deletions at tandem repeats.
Given that, due to its unique mutational and physico-chemical properties, serine has been identified as a mutational hub (Creixell et al., 2012b) and thereby a likely result of cancer mutations, we speculate that through such Ser-to-Thr signaling rewiring cancer cells might evolve less dependency on serine signaling.
Each of these chemicals may have its unique mutational signature.
Each sub-region can be represented by a unique evolutionary tree, called gene tree or perfect phylogeny (PP) (Griffiths, 2001), whose topology approximates the mutational history of the haplotypes therein.
