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Centrosome polarisation to the plasma membrane is unusual in most cell types but is well documented during primary cilia formation, when the centrosome, or 'basal body', migrates to a site at the cell surface and forms the anchor for the elongation of microtubules which form the core of the cilia and which project out from the surface and are surrounded by a unique membrane sheath [ 17- 20].
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CB5005, a rationally designed CPP that targets and inhibits intracellular NF-κB activation, is constituted by a unique membrane-permeable sequence (CB5005M) cascading to a NF-κB nuclear localization sequence (CB5005N).
AKAP7β differs from AKAP7α by the inclusion of a third exon which imparts a unique membrane localization that differs from that found for AKAP7α [ 46].
In the first step of AP formation, a unique membrane called the phagophore sequesters cytoplasmic constituents.
Myelin is a biochemically unique membrane, containing a specific set of proteins.
The membrane is synthesized by a unique combination of 'grafting-from' and molecular imprinting technologies.
Photoreceptor's membrane is characterised by a unique composition of lipids, predominantly containing PUFAs, with the most abundant representative being docosahexanoic acid (DHA) (22 6 ω3), exclusively of dietary origin.
In addition, recent studies have shown that LC3, an autophagy-related, ubiquitin-like modifier, is processed by a unique protein activation/conjugation system to form autophagosomal membranes in cancer cells during autophagy.
At present, more than 350 unique membrane protein structures solved by X-ray crystallography (http://blanco.biomol.uci.edu/mpstruc/exp/list, Stephen White Lab at UC Irvine) are available in the Protein Data Bank.
Further, the precision of the arraying equipment facilitates deposition of unique membrane compositions in specific corrals of a membrane array.
These obligate intracellular bacteria are distinguished by a unique biphasic developmental cycle, which includes proliferation in a membrane-bound compartment termed inclusion.
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