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We concluded that LPS-induced small intestinal injury is initiated by a threshold dose of ∼0.125 mg/kg body weight.
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HVD modeling can also involve an assumption that a threshold dose defined by dichotomizing a continuous apical response has a log-normal distribution.
This suggests that there is a threshold dose for growth stimulation by LA which, together with that in the diet, amounted to 3.8% of the total caloric intake.
Non-linear dose responses suggest that a threshold dose is required in order to induce an adverse effect.
Both effects are supposed to be induced without a threshold dose [5, 6].
In addition, a tolerance dose, in essence a threshold dose, was defined above which liver parenchyma would be significantly damaged.
We could have shown a threshold dose if we examined an intermediate time point.
A threshold dose at which an adaptive response was not induced was demonstrated for osteosarcomas.
The potential for non-linear dose response relationships (e.g., a threshold dose response) needs to be considered consistently.
Under these circumstances, exogenous estradiol is not expected to provide a threshold dose.
An acute gamma-irradiation of male mice destabilizes the sperm genome and F1 brain genome, indicating a transgenerational instability triggered by a certain threshold dose of acute paternal irradiation [ 88].
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CEO of Professional Science Editing for Scientists @ prosciediting.com