Sentence examples for by a third hydroxylation from inspiring English sources
HIF transactivation is also regulated by a third hydroxylation.
The production of hydroxyquinol could be due to the action of a separate hydroquinone monooxygenase, or it could be caused by a second hydroxylation step by the 4-FP monooxygenase.
Instead, upon conversion of hydroquinone by strain IF1, we observed the formation of a transient metabolite that was identified as hydroxyquinol, indicating that a second hydroxylation takes place before ring fission.
The active form of vitamin D results from a second hydroxylation of 25-OHD in the 1-α position to form 1α,25-Dihydroxyvitamin D (1,25(OH)2D).
Third hydroxylation was proved by the detection of traces of 1,2,4-trihydroxybenzene and hydroxy-p-benzoquinone (Figure 1).
Tyr orthoquinone is produced by a second oxidation after oxidative hydroxylation (see " Electrochemical cell").
If the mechanism of RebC includes two hydroxylation steps, one could imagine that the first hydroxylated intermediate that is formed is held in place in the active site by an ordered "melting helix", while the newly reoxidized FAD could swing OUT for rereduction by a second molecule of NADH, in a step that might mimic state 3 of pHBH (8, 13, 28).
The kidneys are involved in the synthesis of the metabolically active form of vitamin D, since the second hydroxylation, stimulated by the parathyroid hormone, occurs in the kidneys.
Second hydroxylation was confirmed by detecting hydroquinone and catechol as well as their oxidation products p-benzoquinone (Figure 1) and o-benzoquinone (Figure 3), respectively.
This first hydroxylation is catalyzed by the CYP27A1 enzyme.
