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Accelerated schedules can be implemented in emergency situations (vaccination on days 0 and 14, followed by a third dose 5 12 mo after the second).
The convulsions continued, and phenobarbital (Fenobarbital natrium NAF 100 mg/ml, NAF, Oslo, Norway) 4 mg/kg was given i.v. followed by a third dose of thiopental at 1 mg/kg.
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Similarly, the healthcare costs and QALYs saved by adding a third dose are minimal when a two dose schedule gives at least 20 years' protection but substantial if it gives only 10 years' protection (fig 2).
The Bexsero vaccine is available on the NHS for babies aged two months, followed by a second dose at four months and a booster at 12 months.
A vaccine to protect against meningitis B is available on the NHS for babies aged two months, followed by a second dose at four months and a booster at 12 months.
Currently the vaccine is only offered to babies aged between two and five months, followed by a second dose at four months and a booster at 12 months.
Heifers were then synchronized either according to the hCG plus EB protocol (hCG-EB, n=637), or by a second dose of cloprostenol 11 d later (PG, n=636).
The purified CD4+CD62L+ Tregs (mCD4CD62L Tregs, 3×106 cells) were administered intraperitoneally into overt diabetic NOD mice in 100 µl PBS/mouse (i.p., close to pancreas) for the first dose, followed by a second dose at 2 million cells in 100 µl PBS/mouse (i.p., close to pancreas) one week later.
In the next experiment using the same initial leukemia dose, but with ip GDTc injections, Donor 1 GDTc expansion was not as great; 15×106 GDTc were administered ip in 10 mice on day 6 followed by a second dose of 10×106 in only 3 mice (Fig. 5b).
Patients received a 90μg/kgg rFVIIa dose, followed by a second dose 6 hours later, if required.
The effect was further enhanced by a second dose of CY at the end of a course of IL-2.
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