Population reconnection after isolation can thus be detected by testing for bimodality and a temporal increase of the variance of the modes.
Studies have shown that the reduction in SIDS in the United States paralleled a temporal increase in deaths caused by 'accidental suffocation and strangulation' [ 38].
In contrast, the rate of severe pre-eclampsia showed a consistent temporal increase by period within every maternal age group (table 2).
A similar temporal increase in reactive oxygen species (ROS) accumulation was detected by staining the liver sections with the H2O2-sensitive fluorescent dye CM-H2DCFDA (Fig 5A).
A third logistic regression analysis, restricting the data to samples collected at Forestier Peninsula, revealed a significant temporal increase in tetraploid tumours among the Forestier devils (χ = 35.0, P < 0.0001, df = 1; Fig. 3C), clearly demonstrating that the overall temporal increase in tetraploid tumours was caused by the increase in tetraploids at the Forestier Peninsula.
In this way, any influence on vaccine efficacy by the emergence and temporal increase in the frequency of new variants, both naturally occurring and induced through the process of genotype replacement, can be determined.
She experienced regression of tumors in the hilar lymph nodes and spleen, accompanied by temporal increases in antibodies to cancer-testis antigen NY-ESO and activation of CD4+ T cells, suggesting that the both humoral and cell-mediated immunity play a role in the abscopal effect.
It was proposed that this temporal increase could have been caused by a learning effect and/or by the previous mammograms being film-screen.
As inferred by the effect of U0126, the temporal increase of cyclin D1 observed with 1 µM H2O2 depended as well on the activation of ERK1/2, while downregulation of cyclin D1 at 50 µM of H2O2 was reverted by the p38 and JNK1/2 inhibitors (Fig. 1C and D).
2. In addition, the early diagnosis of cancers due to lead time may exacerbate the underlying temporal increase by bringing forward in time future higher rates of disease.
