When, despite a systematic titration plan, glargine fails to reduce fasting plasma glucose below10 mmol/l within the first 12 weeks, potentially important problems may be suspected.
When lifestyle measures and oral antihyperglycemic agents are no longer sufficient, the addition of basal insulin optimized by systematic titration of dosage can restore glycated hemoglobin (HbA1c) to 7.0% for 50 60% of people with type 2 diabetes (2, 4, 5).
The Treat-to-Target Trial showed that initiation and systematic titration of insulin glargine using a simple algorithm enables a majority of individuals to achieve an HbA1c level <7% with low rates of hypoglycaemia [ 2].
Glargine doses were increased every 2 days by 2 units until fasting PG reached <5.6 mmol/l, while the systematic titration of detemir involved three steps to obtain both fasting and predinner PG of <5.6 mmol/l (4).
A larger number of titrations are shown here than in panel A to prevent panel A from being overcrowded; each fold-increase was determined by a full stoichiometric titration where each titration was completely and fully saturated.
After titration addition of a formaldehyde:acetone mixture was repeated followed by a second titration, until the solution no longer turned red.
The acid value was determined by a standard titration method as specified in ASTM D664 [15].
Graphene oxide wrapped alumina (GO/Al2O3) composites were synthesized by a facile titration method using Al2O3 colloid as a titrant.
The titration of insulin doses was monitored by Quintiles and reviewed by a blinded titration committee.
The amount of coating protein was optimized by a chessboard titration protocol (20 ).
