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The absorbable biomaterial is strong yet flexible, and degrades in vivo at least in part by a surface erosion process.
Here degradation would occur slowly by a surface erosion mechanism.
As PTMC degrades by a surface erosion process, it is possible to extend the degradation time by increasing the thickness of the specimens and by reducing the surface-to-volume ratio.
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In buffer, PTMC released only small amounts of antibiotics during the first 2 weeks, but in a lipase solution (where PTMC degrades by surface erosion), this was accompanied by a high rate of release of antibiotics similar to that observed for non-biodegradable Septopal beads made from PMMA.
Overall, PTMC has good biocompatibility and degrades enzymatically in a uniform manner by surface erosion; thus, it may provide sustained high antibiotic release rates.
We have found that a repetitive pulsatile drug release with a certain time interval is observed from a monolithic hydrogel device by surface erosion of the hydrogel.
Mechanical force significantly increased solid loss by causing surface erosion.
When mechanical force is not present, a maximum of 61% of the solids in the raw carrot samples could be released into gastric media in 4 h by diffusion, while mechanical force significantly increased solid loss by causing surface erosion.
A minimum-age estimate for Ferrar Drifts calculated by assuming zero surface erosion indicates that the oldest moraine, Ferrar 4, was deposited at least ∼ 3400 ka.
Copolymers degraded mainly by surface erosion but the bulk erosion pattern also appeared at the initial time of degradation for formulation 30% and 40%.
Tetracycline release from such bioerodible delivery system occurs predominantly by surface erosion of the polymeric matrix, leading to kinetics which can be zero order.
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