Concerning macroscopic morphology, the production of an adhesive compound could be one of the reasons for the initial aggregation of conidia to form pellet nuclei, enabling the further formation of pellets by the subsequent aggregation of small clamps of germinated conidia (Prosser and Tough 1991).
The aggregation process is primarily affected by pH [ 12] and generates nanospheres with a hydrodynamic radius of approximately 20 nm [ 13], but larger assemblies can also be formed by subsequent aggregation of the nanospheres [ 14, 15].
The antigenicity decrease at above 90 °C can be attributed to the destruction or masking of conformational epitopes exposed to the surface of the molecule by sulfhydryl/disulfide exchange and subsequent aggregation (Kleber and Hinrichs 2007).
Haritunians et al. (2008) showed that cucurbitacin B prominently alters the cytoskeletal network of leukemic cells by induces improper polymerization and subsequent aggregation of F-actin [ 28].
In addition, DYRK1A might also contribute to the AD-like pathology by phosphorylating Tau, leading to further phosphorylation by glycogen synthase kinase 3β and subsequent aggregation of Tau into neurofibrillary tangles (Liu et al., 2008).
According to this hypothesis, cleavage of the amyloid precursor protein at the membrane of a neuronal cell produces Aβ, subsequent aggregation and fibril formation of Aβ in extracellular fluid produce a neuritic plaque, and neuronal death is caused by toxicity of prefibrillar intermediates or mature fibrils, which eventually causes AD.
It does not consider the subsequent aggregation of donations or a time dependence of the parameter τ describing the mean-field interaction between potential and actual donators.
In addition, we found that cosolubilization of nondetergent sulfobetaines (NDSBs) reduced oligomerization and subsequent aggregation of compounds by shifting the equilibrium toward the monomers.
The subsequent aggregation seemed to be promoted not only by lowering a solvent quality but also by increasing the effective concentration, accompanied by the conformational transition.
To aggregate α-synuclein must undergo a conformational change, however, the mechanism behind this change and subsequent aggregation in PD remains to be determined.
