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We have previously reported that the reduction in testis size in SCARKO mice as compared to littermate controls is accompanied by a striking decrease in tubular diameter (down to 61% of the control on day 50) and an even more marked decrease in lumen formation (down to 32% of the control when expressed as a percentage of testis volume) [10].
In addition, we show that APP serves a unique, non-redundant physiological function for spine structure, as evidenced by a striking decrease in spine density selectively in APP-KO mice, in particular a reduction in the proportion of mushroom spines thought to represent mature synapses.
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By immunohistochemistry, we recognised a striking decrease in the total number of nerve fibres that express the general neuronal marker PGP9.5 in the BM of diabetic patients with neuropathic (T2DM-N) and neuropathic/ischaemic complications (T2DM-NI) (Fig. 1a, ANOVA p < 0.001).
This fact is also observed in our cancer model, as determined by µCT analyses that reveal a striking decrease in trabecular bone content.
Such a striking decrease can be explained by the occurrence of the local HPAI outbreaks instead of the imported infections.
We demonstrate that WIF1 caused a striking decrease in salivary gland CSC number as assessed by a reduction in cells with enhanced ALDH activity and spheroid formation, an in vitro measure of stem cell self-renewal and pluripotency.
On the other hand, DMP1-caPTHR1 transgenic mice exhibited a striking decrease in Sost transcripts and sclerostin protein, as determined by quantitative RT-PCR, Western blot analysis, and immunohistochemistry (Figure 4A, B and C).
A striking decrease in β-catenin was seen in Atmin Gpg6/Gpg6 by immunofluorescence (Fig. 6B) compared with WT (Fig. 6A) and western blotting confirmed a 40% reduction in both total and active β-catenin (Fig. 6E, F and I).
A striking decrease of MS and a negligible ferromagnetic behavior for the annealed films are found and shown in Figure6a.
A striking decrease in square-law slope upon addition of cholesterol denotes stiffening relative to the pure lipid bilayers that is diminished in the case of lanosterol.
Cells that relied on 1/3 ΨCTD RNAP-II exhibited a striking decrease in SL RNA steady-state levels; there was a 70% decrease on day 1 and a 85% decrease by day 2. In contrast, cells containing 2/3 ΨCTD RNAP-II maintained SL RNA levels.
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