Sentence examples for by a stepwise accumulation from inspiring English sources

Cancer has been traditionally typified by a stepwise accumulation of mutations in key oncogenes and tumor suppressors [ 1].

Table 1 shows the increase in the ciprofloxacin MICs of our isolates which was accompanied by a stepwise accumulation of FQ resistance determinants.

A stepwise accumulation of mutations in different pathways constitutes a hallmark of colorectal cancer development.

Like tBRD-1 alSa Sa, TAF1 and Polycomb showed a stepwise accumulation at the nucleolus.

Indeed, the currently accepted model of oncogenesis corresponds to a stepwise accumulation of genomic defects.

The theory of incessant ovulation hypothesizes that repetitive wounding of the ovarian surface epithelium and cell proliferation in postovulatory repair result in a stepwise accumulation of genomic abnormalities.

The deterioration was caused by recurrence of disc extrusion at the initial herniation site and shows that disc extrusions in chondrodystrophic dogs (mainly Hansen type I protrusions) may progress over several days and with a stepwise accumulation of disc material in the spinal canal.

These findings indicated that the decreased susceptibility to carbapenems in K. pneumoniae may arise by the stepwise accumulation of multiple carbapenem resistance determinants in different clones.

In principle, a host bearing bacteria subject to genomic decay can acquire the complete metabolic pathway by stepwise accumulation of genes coding individual reactions.

Second, cancer evolves through a process of stepwise accumulation of genetic alterations that result in uncontrolled cell proliferation and a lack of response to normal apoptotic stimuli.

With sequential dominant clones, leukaemia evolution would be represented by an essentially linear architecture with stepwise accumulation of driver mutations (Fig. 3A).