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This complexity raises a conceptual challenge, namely to define whether a particular cellular response requires assembly of the complete PPI network of interest or can be driven by a specific interaction.
These results suggest that the mechanism of hASC adhesion to MBP bFGF immobilized on a PS substrate is mediated by a specific interaction between bFGF and heparin, and that the adhesion mechanism might provide an insight into the design of biomaterials to control the fate of stem cells.
Since nearly all of the point mutations found are on the surface of the fluorescent proteins, it is very likely that the optimal orientation is caused by a specific interaction between the CyPet and YPet beta barrels in one tandem construct [37].
This arrangement is promoted by a specific interaction of each polymerase with a 5′-P moiety as previously proposed (Brissett et al., 2007).
The biological activity is mediated by a specific interaction with the I prostanoid (IP) membrane receptor [ 25], the same receptor as prostaglandin I2.
This occurs by a specific interaction of the H3K27me3 modification with the chromodomain of the CBX protein found in canonical PRC1 complexes 101.
Similar(51)
E1 activates and links free ubiquitins that will be transferred to one of the E2 enzymes, whereas E3 ligase enzymes promote ubiquitylation by mediating a specific interaction between E2 enzymes and the target protein.
E1 activates and links free ubiquitins that will be transferred to one of the E2 enzymes, while at the same time E3 ligase enzymes promote ubiquitylation by mediating a specific interaction between E2 enzymes and the target protein [ 8].
These results also confirm our earlier conclusion that curing of [URE3] by Ydj1p requires a specific interaction with Hsp70 [63].
Optimal encapsulation is achieved by induction of a specific interaction between the enzyme and the lipid surface.
PKD1 protein was pulled down by both GST FHL1 and GST FHL2, but not by GST alone, indicating a specific interaction with both FHL1 and FHL2.
More suggestions(15)
by a significant interaction
by a complementary interaction
by a specific organ
by a weak interaction
by a synergistic interaction
by a specific body
by a specific virus
by a homospecific interaction
by a direct interaction
by a specific scene
by a specific conductivity
by a specific organism
by a specific microorganism
by a specific officer
by a specific author
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