Our method estimates a disease risk associated to a specific exposure profile by robustly accounting for the different dimensions of exposure and will be helpful in general to give further insight into the effect of exposures that are accumulated through different time patterns.
It also suggests associations of occupational exposures with hormone regulation that vary by gender and specific exposure group and implies biologic pathways by which these hormones may be operative.
24 The baseline hazard was combined with the parameters estimated from the Cox model to derive the survival curve of a generic cohort member, characterised by a specific history of exposure and covariate values.
Our PCA produced four factors of which three were clearly defined by specific exposure groups (PBDEs, phthalates, organochlorines).
Proxy monitoring: while it is the intention of the steps outlined in the current document to convert HBM data into risk management and policy making options, the most efficient way of controlling human dose may not be by controlling human exposure, but by monitoring and controlling a specific, main, exposure route and setting limits for a proxy.
As an endocrine organ, which plays a critical role in all aspects of pregnancy maintenance and fetal development, the placenta can provide insight into mechanisms by which specific exposures and risk factors are associated with outcomes measured at delivery.
This will require an understanding of the genes affected by specific exposures and the consequence of alterations in these genes or their products, which in turn will require an understanding of the pathways critical in development.
The workers answered a questionnaire and were classified into two occupational groups by specific exposures based on the reported designation of their specific task.
Polymorphisms that alter the expression levels of membrane transporters could determine the effective dosage of a drug by altering the systemic or tissue specific exposure to the drug.
It is a specific biological indicator, sensitive, stable over time and temperature, not influenced by specific exposures prior to the analysis and easy to obtain [ 38, 39].
