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Exact(5)
Such differences are difficult to identify by a simple sequence or structural alignment.
During the threading, I-TASSER generates the template alignments by a simple sequence Profile-Profile Alignment approach constrained with the secondary structure matches.
Many homologues of this protein can be found by a simple sequence search, but this structure seems to be so distorted, that a method based on recognising regular secondary structure finds no similar structures in the protein data bank [ 23].
Thus our bioinformatic analysis shows that CoTC terminators are not characterized by a simple sequence motif and indicates that factors apart from DNA sequence are involved in the CoTC termination process.
Combining these data with our understanding of the role of AT-rich sequences in the human β-globin terminator (Dye and Proudfoot, 2001: White et al., 2013) enables us to state that CoTC terminator sequences are complex and are not characterized by a simple sequence motif.
Similar(54)
The first study to elucidate the CD36-FA binding site was done by Baillie et al, 13 suggesting a potential site by utilizing a simple sequence alignment and without any validation.
This seems to be an easy option if the proteins share high sequence similarity, as they can be matched to each other by performing a simple sequence matching.
These observations cannot be explained by a simple sequence-to-function correlation.
The winners hit this target on the diagramed deal by reaching four spades with a simple sequence.
We suggest that the extant common architectures of plant Class I, Class II and Class III formins may have been produced by a relatively simple sequence of evolutionary events that has maintained a continuity of the Rho-FH2 and/or membrane-FH2 association, while the molecular mechanisms of these connections have changed.
PMP-targeting signals (mPTSs) may involve different regions of the PMPs and are not characterized by a simple consensus sequence.
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