Sentence examples for by a sequence alignment from inspiring English sources
Typical sequence motifs of CpMRP were identified by a sequence alignment using NCBI Protein BLAST (Altschul et al., 1990).
The location of the KLHL9 p.L95F mutation within the complex was identified by a sequence alignment of the BTB domains from promyelocytic leukemia zinc finger protein and KLHL9.
Using an E-value threshold of 10 190, corresponding to ∼75% identity, the clusters are isofunctional as judged by a sequence alignment.
The simplest case of the problem occurs when an initial correspondence map between the residue pairs is provided by a sequence alignment procedure.
The deleted region was determined by a sequence alignment of TS domains from higher eukaryotes and a conserved core region of the domain was chosen for mutational analysis (Supplementary information, Figure S1A).
The presence of the typical functional elements of FAD-like enzymes was analyzed using bioinformatics tools: six transmembrane domains were identified by TMpred (data not shown) and three His motifs were identified by a sequence alignment of proteins with characterized FAD-Like enzymes (Additional file 15: Figure S7).
10.7554/eLife.00290.011 Figure 4. Kif2a is regulated by importin α. (A ) Sequence alignment of region surrounding the nuclear localization signal (NLS) identified using PredictNLS program.
Methods for designing degenerate primers start by finding highly conserved regions across a sequence alignment, e.g. by solving a Set Covering Problem (Jabado et al., 2006).
To bypass the large memory requirement, slider [13] proposes a sequence alignment by merge-sorting the reference genome subsequences and read sequences.
An alternative approach to determine nucleotide substitution rate variation among different genomic regions is to plot differences as averages by sliding a window along a sequence alignment [ 70].
Furthermore, a sequence alignment presented by Muhle-Goll et al. indicated that this latter motif in EphA1 does not seem to be conserved across different receptor tyrosine kinase families.
