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In favor of consistency with a selective sweep scenario, we may also mention that SLC2A4 is within a genomic region where LD is in general low (supplementary File S1), and therefore, the signature of natural selection determined by a selective sweep would be necessarily restricted to a small region.
This would be expected for a locus which either recently completed a selective sweep but has not yet accumulated new mutations or is currently being swept of variation by a selective sweep but fixation of the selected allele has not yet occurred.
The chromosomal length affected by a selective sweep mainly depends on the strength of selection, the recombination rate, the population size, and the time elapsed since the sweep [ 47- 49].
In addition to producing divergence at the target of selection, such adaptive evolution is often accompanied by a selective sweep, which may create additional genetic divergence between strains [ 10].
The severe reduction in nucleotide variation at OsAMT1 1 in rice was caused by a selective sweep around OsAMT1 1, which may reflect the nitrogen uptake system under strong selection by the paddy soil during the domestication of rice.
We ranked the 212 regions with respect to their genetic width in centimorgans (Fig. 4B, and table S37) because the size of a region affected by a selective sweep will be larger the fewer generations it took for the sweep to reach fixation, as fewer recombination events will then have occurred during the sweep.
Similar(40)
The most often detected M. bovis strains in Mali with spoligotype pattern SB0300 could have evolved from strains with spoligotype pattern SB0944 either by drift or a selective sweep.
This low value is a signature of positive selection, most likely due to a selective sweep caused by genetic hitchhiking [16].
A selective sweep by antibiotic resistant strains would be expected to decrease genetic complexity of the gonococcal population and thus cause a decrease in effective strain population size.
In addition, the population structure revealed by the individual-level of resolution provided by CRISPRs shows no evidence of a selective sweep or an epidemic structure in which one set of sequences is at high abundance relative to the rest of the population.
Therefore there is no evidence of a selective sweep driven by these variant alleles at DEFB126.
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