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A structure based suppression strategy permits the inactive variant Flp(W330A) to be rescued by a second site mutation A339M.
Next year it will open an assembly line for the single-aisle A320 in China, which will be followed by a second site for making composite components.
Importantly, this growth deficiency was abrogated by a second site mutation that prevents filament formation (T49E), indicating that filament formation is the cause of the reduced growth rate.
The phenotypic defect in DNA sensing was consistent in cells from four separate genotypes, ruling out the possibility that it was caused by a second site mutation.
Since Utx /Df 2L BSC143 transheterozygotes and Utx Δ homozygotes do not show this phenotype, it seems likely that this rough eye phenotype is caused by a second site mutation on the 2L chromosome arm carrying the Utx allele.
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The city office discovered last year that it had been violating the state election law for decades by setting up a second site at nursing homes in districts where a primary voting site already existed.
Diffusion phase: A second site by site visit is carried out.
This defect could be restored by adding exogenous cAMP or by a second-site mutation in SUM1 encoding the regulatory subunit of PKA, resulting in constitutive activation of the PKA catalytic subunit [47].
The deleterious effect of a mutation can be reverted by a second-site interacting residue.
In the alternative model, a deleterious mutation occurs first, being subsequently compensated by a second-site substitution.
The replication defect imposed by SP1-A3V was reversed by a second-site compensatory mutation in CA (CA-G225S).
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