Sentence examples for by a second mutation from inspiring English sources

Importantly, this variant peptide turns into an Akt recognition sequence by a second mutation of Ile155Arg, because the doubly mutated sequence has a RR RGD SF stretch that conforms to the Akt recognition sequence (RxRxx T/S F; T/S, phosphorylation site).

There are also PRD residues that determine binding but not binding specificity in that if they are mutated, the resulting effect on binding cannot be restored by a second mutation.

However, the T16189C polymorphism can be accompanied by a second mutation for example at position 16192, interrupting the poly-C tract (Figure 1C).

To test whether the R23E mutant effect could be neutralized by a second mutation, we introduced the inhibitory T49E mutation into the R23E variant.

As mentioned above, most proteins essential for Tfpa biogenesis are actually dispensable for filament assembly per se since the piliation defect in the corresponding genes could be suppressed by a second mutation in pilT.

For example, a germline mutation in GNAS may be followed by a second mutation in the other allele during development and both be retained by a finite number of progenitor cells in the postnatal state.

The possibility that Pro509 is a specific residue required for a mitotic function independent of RNase activity was addressed by examining a second mutation in the RNB domain that is located almost 300 residues C-terminal of dis3-54 alsoalso reduced RNase activity (Thr808→Ala; Thr808→Ala

However, unlike CFTR-ΔF508, Yor1-ΔF670 does not retain membrane transport function, a problem that the authors circumvented by introducing a second mutation (R1116T) that restores partial pump function.

Evidence is presented that the accumulated Lac+ revertant colonies are initiated by small-effect (weakly Lac+) mutants that arise prior to selection and improve by acquiring a second mutation during growth under selection.

The problem, which had bedeviled targeted therapies for other cancers, was that while PLX4032 blocked the protein made by one mutated gene, a second mutation now seemed to be driving the cancer's growth.

By contrast, introducing a second mutation, which abolishes DNA binding specificity, (Boer et al., 2014) (MPNm2-BSH), blocked activity of the fusion protein.