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Attenuation of mechanical hyperalgesia was extended by a second administration when the effect of the first had diminished.
Antigen-specific antibody responses, but typically not T cell responses, were boosted by a second administration of adenovector.
Study 1: GOtumor-bearinging mice (11.5 months old) were injected with a priming administration of 5 or 10 MBq of 177Lu-octreotate followed by a second administration (24 h later) of 10 or 5 MBq 177Lu-octreotate, respectively.
Subsequent rechallenge with intra-articular IL-1 induced flare of arthritis in all groups, which could be effectively suppressed by a second administration of mBSA-exposed modified DC.
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Baseline testing was followed by a second test administration at six months.
This injection was followed 2 weeks later by a second s.c. administration of the same dose with IFA.
When comparing response indices after the first to the ones after the second immunization in the PEV301 50 µg groups, the difference was borderline significant (p = 0.09) indicating that the initial response was possibly boosted by the second administration.
When comparing response indices after the first to the ones after the second immunization in the 10 µg group, the difference was borderline significant (p = 0.056) indicating that the initial response was boosted by the second administration.
A 5-day protocol was used in which an intracerebral needle injury (5-min insertion of a 28-gauge needle with infusion of 10 μl PBS) was created 6 h after intraperitoneal NMO-IgG administration, and followed 18 h later by a second NMO-IgG administration.
Saturation was also avoided by giving the second administration no earlier than 24 h after the priming activity.
But working ourselves into a state of indignation about a second Bush administration driven by militant illogic gets us nowhere.
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