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Overexpression of ENC1 and Keap1 were confirmed by a robust induction of ENC1 and Keap1 mRNA (Fig. 2C, ENC1 and Keap1 panels).
Med-induced TRAIL sensitization involved both the extrinsic and the intrinsic pathways of apoptosis, as evidenced by a robust induction of cleaved caspase-8 and caspase-9.
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Both reporters showed a robust induction by geneticin and gentamicin.
First, stable cell lines were verified for Id3 protein induction by Tet (Fig. 1A) and a robust induction of Id3 mRNA (seven- to eightfold) was confirmed by semiquantitative reverse transcriptase-mediated PCR (RT-PCR) as well as by qRT-PCR (Fig. S1).
A conditionally essential nutrient, Gln induces Hsf1 gene activation and HSF1 expression by activating its transcription, leading to a robust induction of HSP72 response [ 49].
In a time course study we could not observe any effect on IFNα1 and IFNβ, whereas a robust induction was seen by exposing cells to Poly I∶C.
This enhancement is likely related to a robust induction of iNOS by the combination with IL-17, as iNOS−/− MSCs didn't present any therapeutic effect on this liver injury model.
Indeed, treatment with 5-FU led to a robust induction of senescence in AGS cells.
Rapamycin feeding elicited a robust induction of cabut as well as CG6770 expression in larvae (Figure 5B).
Challenge of mosquito cells with bacteria typically results in a robust induction of AMP expression in the cells.
Consistent with our studies of TLR6 transcript, we found a robust induction of TLR6 protein with hypoxia (Figure 3C).
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