Typically, secreted mucins are expressed exclusively by specialised epithelial cells, are secreted in the mucus, and display a restricted expression pattern within the human body.
Within the hindgut, JAK/STAT signalling is activated by the localised expression of upd (os - FlyBase) within the small intestine, a restricted expression domain that is required for correct hindgut elongation (Johansen et al., 2003b; Hombría et al., 2005).
By using Dpl-Fc as a tool to probe brain histoblots, we firstly identified a restricted expression of Dpl binding partners in the granule cells of either wild-type or PrPC-devoid mice [14].
We determined a restricted expression with very high levels of expression in brain and testis, an expression pattern previously identified by northern blot and reverse transcriptase-PCR analysis [ 15].
A small subset of the genes show a restricted expression pattern in normal tissues.
From EST analysis results, SLC30A10 had a restricted expression to fetal liver and fetal brain.
It also exhibits a restricted expression in mouse, notably in brain and testes [ 51].
Sn seems thus a promising target for cell-directed therapy, a strategy that is further encouraged by the restricted expression pattern of Sn limiting unwanted side effects.
An apical region devoid of six3 expression, 'filled' by the restricted expression of foxj, nkx3, hox and irx, thus represents a larval-specific transcription factor signature that molecularly defines the apical organ in several distinct, phylogenetically remote neuralian groups such as anemone and annelid and lends strong support to its evolutionary conservation (see Discussion).
A more restricted expression pattern is shown by Dll4, that is exclusively expressed by V2 differentiating neurons [14], [33], and by Jag2, which is expressed in differentiated MNs [32].
