For crossbred animals, a highly accurate imputed 60 K crossbred dataset can be achieved from 8 K by using a reference population that combines both parental breeds.
This could be one reason why imputation of a purebred or crossbred population by using a reference population that consists of Landrace animals only, always performed better than by using a Yorkshire reference population, although all other important factors (such as relationships, LD and MAF) were very similar in the two pure breeds.
Briefly, signal intensity (log R ratio, LRR) and allelic intensity (B allele frequency, BAF) values were extracted, and used by PennCNV to detect CNVs in our bull by comparing with a reference population of 138 other Holstein bulls that have been genotyped (data not shown) [ 61].
Increases in apixaban exposure of 100% would be expected to increase bleeding risk by 18% relative to a reference population and represents the change in exposure that might be encountered in the presence of a strong inhibitor of cytochrome P3A4 and P-glycoprotein.
The efficiency of investing in CB information to enable genomic selection of PB animals for CB performance was explored by varying the proportion of PB and CB animals in a reference population, or by adding CB individuals to an existing PB reference population.
Following a common empirical regularity, we use the U.S National Center for Health Statistics (NCHS) as recommended by the World Health Organization (WHO) as a reference population.
A single strain was identified in 20 cases, clearly distinguishable from other local strains and a reference population by WGS.
Lastly, by comparing published data to a reference population, we identified an even higher risk region within 543-713 that was not previously recognized for desmoid tumors.
The ratio comes from dividing the observed number diagnosed (the number of cases of a specific disease) within a reference population by the expected number within the general population.
Standardized risk scores for ACG, DCG, the CDPS, and the RxRisk risk measures were calculated by dividing each patient's predicted score by the average total expenditure for a reference population (veterans in the ACQUIP study).
