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We tried to analyse the multigenerational demographic responses of sexual Artemia franciscana and asexual Artemia parthenogenetica due to chronic genotoxicity by a reference mutagen, ethyl methane sulfonate (EMS).
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Homopolymer errors would obscure mutations caused by a frameshift mutagen [31].
Such intermediate or leaky waxy mutants were frequent among mutants induced by a chemical mutagen, EMS.
Recently, localized mutation clusters were discovered in yeast mutants obtained by a different mutagen, methyl metanesulfonate (MMS) [ 3].
where clustered mutations were induced in yeast by a different mutagen- MMS.
"Mutation rates can be increased by adding a mutagen or by inhibiting DNA repair machinery". Animal tests to measure threshold size may be possible by targeting a tumor with pulsed application of a drug and studying the response.
Our results showed that D. gnidium leaf extracts possess an antigenotoxic effect against the nitrofurantoin a mutagen of reference.
These different incidences could be explained by physiological parameters, but also by a differential exposure to mutagens.
In conclusion, FMDV populations doomed to extinction failure because of the dominance of a mutagen-resistant mutation, could still be driven towards extinction by a combination treatment involving another mutagen and a non-mutagenic antiviral inhibitor.
But fame turned to notoriety later that decade when research by two scientists, Arlene Blum and Bruce N. Ames, concluded that Tris is a mutagen, a gene-altering agent.
Unlike previous studies pointing to alternative, high-fidelity NHEJ in hESCs [ 4], in these experiments [ 5] DSBs were introduced by ionizing radiation, a typical environmental mutagen and clastogen.
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