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A similar number of putative novel gene loci (4431) was obtained by a reference alignment and prediction approach starting from the same dataset [ 33] (data not shown).
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and on the other hand, the biological accuracy, estimated by comparison with a reference alignment.
To reduce the complexity, we first use the 1-best phone transcription generated by the LVCSR decoder as a reference alignment to divide the whole speech utterance into time slots, and then fill each slot using N-best phone hypotheses.
One such tool to embody this approach is Pagan [ 14], a phylogeny-aware multiple sequence alignment method capable of extending a reference alignment by placing a query sequence into its correct phylogenetic context.
As shown in Figure 8, our method can correctly align >90% of the positions judged by the reference alignment (regardless of which structural alignment tools are used to generate it).
Thus a causal variant that manifests as a local eQTL may be obscured by the common reference alignment approach.
Figures 5 and 6 show the average sensitivity and precision of the programs, with results grouped by reference alignment sequence identity.
The reference-dependent accuracy is defined as the percentage of correctly aligned positions judged by the reference alignments.
The reference-dependent accuracy is defined as the percentage of correctly aligned positions judged by the reference alignments, which are built using our in-house tool DeepAlign (Wang et al., 2013).
The reference-dependent alignment accuracy is calculated as the percentage of correctly aligned positions judged by reference alignments, which are generated by structural alignment programs.
The context of our study is an ontology network consisting of several taxonomies networked by partial reference alignments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com