To this end, we depleted smo-1 lf bet-1 lf double mutants of egl-15 by either performing RNAi or using a reduced function allele; we found that the penetrance of the myosin depletion phenotype is decreased by 56%, from 34%to15%5%, (P = 0.001; Table 1) and by 35%, from 34% to 22%, (P = 0.042; Table 1), respectively.
However, evaluation of various data showed that the loss of selectivity with annealing is governed by a reduced effective work function of the TMOs.
Cervical dysfunction is characterised by reduced function of the deep stabilising muscles of the neck.
Taken together, the evidence suggests that cerebellar learning defects in autism mouse models may be strongly shaped by reduced function in the olivocerebellar circuit and associated synaptic plasticity mechanisms.
Among phospholipids secreted by cells expressing the A116D mutation into culture supernatant, PC was again decreased by 14% and LPC was increased by 184%, in accordance with a reduced surfactant function [ 41, 43].
The developmental abnormalities in individuals with SLOS might also be caused by reduced functioning of the sonic hedgehog (SHH) signaling pathway, which is required for normal embryonic development of the CNS, limbs and facial features (Maity et al., 2005).
Although the D360N mutation is not within a predicted transmembrane segment (Figure 3C and S4), the suppression by laz1-4 may be due to reduced function and/or mislocation of the mutated LAZ1 protein (see below).
Through using vision and changing the technique they used, several participants could compensate for reduced function by themselves.
