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These trends were confirmed by a recent large international prevalence survey in ICUs, which reported infections due to Candida and Aspergillus in 17% and 1.4% patients, respectively [3].
These potential biases are taken into account by a recent large study of patients with BD (n = 587), thereby confirming childhood trauma as being associated with more severe clinical features in BD, including an earlier age of onset, an increased risk of at least one lifetime suicide attempt, rapid cycling, an increased number of mood episodes and substance misuse (Etain et al. 2013a).
Other well-known predictors for delirium in the general ICU population identified by a recent large systematic review [26] seem to have no significant influence on the development of delirium in the context of BSI, such as altered level of consciousness, or surgery.
This recommendation, by the way, has not been supported by a recent large trial where a transfusion trigger of 7 g/dL, as compared with transfusion of 9 g/dL, led to fewer transfusions but similar mortality at 90 days in patients with septic shock [42].
This conclusion is also supported by a recent large cohort study from Israel with 12.071 participants.
The favourable role of IF-RT is suggested by a recent large retrospective analysis (Zinzani et al, 2002).
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By contrast, a recent large observational study on 1912 German men showed an inverse association between hepatic steatosis and serum testosterone levels [ 25], a finding consistent with that in our study.
Moreover, as revealed by a recent large-scale survey conducted by British and Chinese researchers, Chinese schoolchildren suffer from extraordinarily high levels of anxiety, depression and psychosomatic stress disorders, which appear to be linked to academic pressures and lack of play".
This finding is contradicted by a recent large-scale national study [ 30], where it is described that the control of hypertension is more effective among urban residents, partially explaining this difference.
In contrast to some optimistic claims made by commercial vendors, off-target effects remain a widespread problem, as illustrated by a recent large-scale screening in which the effects of over 160000 constructs from three libraries (at an average of ∼7 RNAi constructs per human gene) on 58 cellular phenotypes were tested (Collinet et al., 2010).
This hypothesis was supported by a recent large-scale, population-based study, which demonstrated that only a very low vitamin D level (<5th percentile of serum 25(OH D) significantly increased the risk of fatal ischemic heart disease after adjustment for traditional cardiovascular risk factors [ 39].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com