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In either case, the increase in %omissions is unlikely to be explained by a primary effect on cognition.
Thus, the excess of muscle development genes in fat and gonads might simply reflect a pleiotropic change caused by a primary effect in muscle.
Embryonic exposure of zebrafish (Danio rerio) to PBDE-47 has been found to lead to cardiac and morphologic defects that appear to be caused by a primary effect on neural function (Lema et al. 2007).
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This supports that autophagy triggered by IFNB1 was a primary effect rather than a secondary stress-induced survival response.
We chose the early time point to identify genes that are likely modulated by 5-AzaC as a primary effect (rather than a secondary down-stream effect of expression changes in other genes).
However, inhibition of ATP hydrolysis in SMPs by proguanil was confirmed to be a primary effect on ATPase by testing the isolated intact enzyme; indeed, the observed IC50 value of 0.67±0.1 μM for isolated ATPase is lower than for SMPs (6.8±0.7 μM).
The organ failure seen in sepsis often debuts after several days, and if mitochondrial dysfunction is a major factor in that development, we do not think that the present study points towards a primary effect caused by a mediator present in the plasma of septic patients, at least not in the skeletal muscle.
Landscapes change constantly from natural and anthropogenic drivers, and land use and land cover changes by humans have been identified as a primary effect of humans on natural systems.
37 Evidence for using alpha-glucosidase inhibitors as monotherapy in the elderly population shows that miglitol, when dosed at 25 mg and 50 mg three times daily with meals, reduced A1c by 0.41%0.5%% after one year, with a primary effect on post-prandial glucose concentrations.
This indicates that TLR2 has a primary effect upon bacterial clearance, which is supported by CD14.
It will have a primary effect on mortality inequality, and also a secondary effect as people respond to the primary effect by increasing their health-promoting behavior.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com