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A third observation is that the identified forkhead element is immediately flanked by a potential binding site for members of the doublesex and mab-3 related transcription factor (DMRT) family so that the core sequence of this binding site (A/T,TGT) [53] is contained within the highly conserved 14bp region (Fig. 6).
The enhanced exclusion and retention of Dex70 seems not explained by a potential binding of the dextran to the residing metformin since this would be expected to lower circulating dextran concentrations, thereby resulting in an overestimation rather than a reduction of their distribution volume and clearance.
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Peaks were annotated using ChIPpeakAnno package [ 47] and only genes characterized by a potential SIRT1 binding within 10Kb from the gene start site were considered.
This may be explained by the small proportion of the genome generally covered by the potential binding sites of a DNA-interacting protein and the resulting small contribution of the enriched component.
A role of Sec7 in phagocytosis is also supported by the potential binding partners as several of them have been implicated in this process and found associated with the phagosome [ 29].
By mutating potential binding sites or phosphorylation sites within the cytoplasmic domain of β-DG we could also potentially restore podosome formation by inhibiting the dominant-negative effect of DG overexpression.
Followed by the potential binding of EGCG with subtype 3g, maximum number of nine H-bonds were in sighted from naringenin (H-bond energy: −4.3324 kJ/mole) and silybin (−7.6386 kJ/mole).
These data could therefore suggest that the improved substrate binding is caused by a potential effector peptide binding-induced repositioning of the PHD1 domain that is coupled to the conformation of the helical loop region which orients itself to optimally bind the substrate.
MecA is proposed to inhibit the Agr system by potential binding on Agr locus.
As suggested by molecular modelling, potential binding interactions of the tetrapeptide inhibitors with the helicase domain might explain the data and structure activity relationships thus obtained.
Fig. 6 Heat map of SiteHopper PatchScores across the Pilot dataset of 1085 protein structures represented by 1706 conserved potential binding sites.
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