Sentence examples for by a polygenic model from inspiring English sources

Therefore, a disorder dominated by a polygenic model will be one in which several common variants of modest effect contribute to risk for disease in each affected individual.

The remaining familial risk is likely to be explained by a polygenic model where breast cancer susceptibility is conferred by a large number of low-penetrance alleles.

The residual familial clustering not accounted for by BRCA1 and BRCA2 mutations is assumed to be explained by a polygenic model with a variance that decreases with increasing age [ 14].

High risk alleles such as BRCA1 and BRCA2 explain less than 20% of the FRR [ 4] and the residual familial risk is best described by a polygenic model comprising multiple variants, each of modest risk [ 5].

It takes into account the simultaneous effects of BRCA1, BRCA2 and the residual familial clustering of breast cancer not accounted by these genes, which is assumed to be explained by a polygenic model [ 14].

It has been shown that ∼3% of variance (corresponding to an AUC of 0.65) (23) in schizophrenia risk can be explained by a polygenic model, including a large number of loci that did not achieve genome-wide significance (29).

A significant proportion of the families are not associated with mutations in BRCA1 or BRCA2 or other known genes [ 2- 5] and may in part be explained by recessive alleles or a polygenic model with risk variants of lower penetrance jointly affecting risk in miscellaneous combinations [ 6- 8].

The fact that the risk increases progressively with the number of affected relatives suggests the effect of a fairly large number of genetic risk groups, consistent with, for example, a polygenic model as proposed by Antoniou et al. [ 12].

The TALLYHO/JngJ (TH) mice are a polygenic model for T2D characterized by obesity, hyperinsulinemia, impaired glucose uptake and tolerance, hyperlipidemia, and hyperglycemia.

TALLYHO/JngJ (TH) mice are a polygenic model for T2D characterized by glucose intolerance and hyperglycemia (limited to males) and show metabolic abnormalities including obesity, insulin resistance, hyperinsulinemia, and hyperlipidemia [ 5- 7].

The non-obese diabetic (NOD) mouse is a polygenic model for type 1 diabetes that is characterized by insulitis, a leukocytic infiltration of the pancreatic islets.