These results emphasize that successful product formation by a heterologous pathway depends on a combination of both the kinetics of the introduced enzyme (hence on the choice of the enzyme) and on successful overexpression, which may be influenced by codon usage.
The degree to which a given signalling cascade is uniquely required for a specific biological response, or can be substituted by an alternative pathway, depends on the cell type, the nature of the response, the strength of the signal and the robustness of the signalling network available for this biological outcome.
This suggests complementary pressures towards an oncogenic pathway depending on telomere lengthening by mutations co-occurring at ATRX, TP53 and (hypothetically) IDH1 in adult brain tumors where the PTEN/EGFR surface signaling axis is not altered.
SPX1 is strongly induced by Pi starvation and usually classified as member of a system signaling pathway depending of SIZ1/PHR1 reviewed in [ 31].
Several pathways are defined for apoptosis such as the extrinsic pathway induced by death receptors, the intrinsic pathway depending mostly on mitochondria, and the endoplasmic reticulum (ER) stress pathway.
Saturability of the components of plasticity implies that the amount of plasticity contributed by each pathway depends on the initial level of strength of the synapses.
We see that the fitness conferred by the metabolic pathway depends strongly on the enzyme production rate constant pEA, except if the nutrient level is always kept within a limited range.
In mammals, the regulation of organ size by the Hippo pathway depends on YAP transcriptional activity and TEADs.
The secretion leads, by two pathways, depending on the substance encountered, to the cleavage and activation of the proclotting enzyme generating the clotting enzyme.
Accordingly, megalin expression is also regulated by signaling pathways depending on ERK and PI3K in PTCs [31], its proteolytic processing can be induced by PKC activation [79] and its cell surface expression is upregulated upon GSK3β inhibition [8].
