In some cases these CD molecules do show a parallel expression pattern, as expected if the gene expression responses are caused by cellular influx.
These datasets are constructed by correlating expression levels of genes, usually measured using a highly parallel expression profiling technology, with the presence of different SNPs.
The collinear OsLTP gene pairs in clade I.1 did not evidence a significantly parallel expression pattern, as most of these genes were not stimulated by the tested stresses.
By contrast, the parallel expression of the cAMP early inducible repressor (ICER), which represses CREB activity by competing for the CREB consensus site, appears downregulated at diagnosis but neither in remission nor in control samples [ 26].
In fact, there was a significant overexpression of MKi67, contrary to what was observed after the short-term treatment, suggesting a depletion of counter-regulatory responses, which was accompanied by a parallel increase in mTOR expression, a serine/threonine protein kinase, important in regulating cell growth, proliferation, motility, survival, protein synthesis, and transcription [ 48].
Finally, we characterized the cell types that form part of the apical organ by profiling by image registration, which allows parallel expression profiling of multiple cells.
Significant reductions in osteogenic and chondrogenic gene expression and an increase in adipogenic gene expression were shown and could be validated by a parallel adipogenic differentiation assay.
Cyp1a2, a notable xenobiotic and drug metabolizer and known target of Ahr, exhibited roughly parallel expression between sexes with maximum relative expression (~1.5 fold) peaking around 6 to 8 weeks followed by declining expression with age.
The shift of ASMCs from synthetic-proliferative to contractile phenotypes is attended by a decrease in M2 and a parallel increase in M3 expression [ 11].
Wnt-pathway activating point mutations of APC or ß-Catenin are commonly found in DTF soft tissue tumors, and a subset of breast carcinomas are characterized by a stromal gene expression signature that parallels the characteristic gene expression signature of DTF tumors [15].
