Sentence examples for by a negative mutant from inspiring English sources

Furthermore, the shear stress induction of JNK was attenuated by a negative mutant of Cbl.

Furthermore, Vpu-induced virion release and removal of BST2 from the cell surface are inhibited by a dominant negative mutant of AP180, a protein required for the assembly of the CCV at the lipid membrane (Kueck and Neil, 2012; Lau et al., 2011).

Using retroviral infections to introduce and express exogenous c-fms genes in Ishikawa cells we also demonstrate proliferation to be partially inhibited by a dominant negative, mutant c-fms gene, yet enhanced approximately 3-fold by a normal c-fms gene, under conditions in which the only source of M-CSF was that produced by the cells.

Interestingly, however, the promoter activity of both pGL3/HCCR-1-P1196 and pGL3/Hconstructs constructs was enhanced by a constitutively active form of Akt whereas it was down-regulated by a dominant negative mutant form of Akt.

The phenotypes induced by depletion of endogenous xWNK4 were rescued by over-expression of wild-type xWNK4, but not by a kinase negative mutant of xWNK4.

Last, we show that in the genetic syndrome of RTH, disruption of T3-dependent histone modifications by a dominant negative mutant TR may lead to inappropriate TSHα secretion.

DRP1-induced excessive mitochondrial fission caused ectopic programmed cell death, and inhibition of DRP1 activity by a dominant-negative mutant or a chemical inhibitor delayed programmed cell death.

In human CD4 T cells, inhibition of p38 MAPK by SB203580 or by a dominant-negative mutant of p38 MAPK reduced the expression of IL-4, IL-5, and IL-13 in response to CD3 and/or CD28 stimulation [ 60, 61], indicating that the p38 MAPK pathway has a critical role in the regulation of Th2 cytokine expression in primary human T cells (Fig. 2).

Therefore, in the present study, we attempted to develop a HCC-specific gene therapy system by expressing a dominant negative mutant form of the PP2A catalytic subunit α (DN-PP2Acα) [ 13] under direct transcriptional control of the AFP enhancer/ pgk promoter, and investigated the therapeutic effects of this system in HCC in vitro and in vivo.

To further address the mechanisms by which calcineurin inhibits autophagy, we manipulated AMPK activity by expressing a dominant negative mutant of AMPK (DN-AMPK), thereby inhibiting endogenous AMPK activity.

In this study, we developed a hepatocellular carcinoma (HCC -specific gene tHCC -specific by expressingenedominantherapyive mutant form of the PP2A catalytic systemt under direct transcriptional control of the AFP enhancer/pgk promoter, and investigated the therapeutic effects of this system in HCC in vitro and in vivo.