EPOR and TPOR signaling is limited by a negative feedback loop employing SHP1 and SHIP phosphatases and suppressors of cytokine signaling (SOCS1, SOCS3) [ 49, 55, 56].
Non-canonical NF-κB is regulated by a negative feedback loop involving NIK-mediated activation of SIX1 and SIX2.
Circulating IGF-1 exerts endocrine action, it regulates growth hormone secretion by a negative feedback mechanism.
Our earlier reverse engineering analysis suggests that the non-linear response can be caused by a negative feedback regulation of photosynthesis.
Many RNA-binding proteins (RBP) regulate their expression levels by a negative feedback loop, in which RBP binds its own pre-mRNA and causes alternative splicing to introduce a PTC.
These results might indicate that NCI-H2122 canls can be affected by a negative feedback upon the MEK kinase inhibition.
Therefore the expression of Mesp2 is tightly regulated by a negative feedback loop in vivo (Oginuma et al., 2008).
Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance towards fluctuations and disturbances.
Production of TSH and TRH is decreased by thyroxine by a negative feedback process.
Together, these observations led to a model in which the proteasome homeostasis is regulated by a negative feedback circuit.
Such results confirms what stated in [22] about the tunability of topologies composed only by a negative feedback loop.
