Sentence examples for by a mutation within from inspiring English sources
Huntington's disease (HD) is a neurodegenerative disease caused by a mutation within the huntingtin gene that induces degeneration within the striatal nuclei, progressing to widespread brain atrophy and death.
The functional role of PRRII in the regulation of the IL2RA gene expression was first evidenced by a mutation within this region inhibiting its transcription [46].
The ability of Cus2 to facilitate U2 snRNA folding is abrogated by a mutation within one of its RRMs that abolishes U2 snRNA binding in vitro [16].
If interaction between the HP1 chromoshadow domain and the PGVLL motif is the main mechanism of ADNP binding to H3K9me3, then association of ADNP with H3K9me3 should be strongly reduced by a mutation within this region.
First, reduced viral fitness caused by a mutation within an epitope can be reverted by subsequent mutations referred to as compensatory mutations.
Finally, we tested whether such a mutation was reciprocated by a mutation within the same repeat A unit, or in all other repeats of that species.
The specificity of the interaction was confirmed by a point mutation within the A.m.H GBD: an exchange of Tyrosine 264 to Alanine was sufficient to completely abrogate binding to Gro (Fig. 3), just like the corresponding mutation in D. melanogaster [ 12].
The disease is most commonly caused by a point mutation within the TTR gene inherited in an autosomal dominant fashion.
TP53 is mostly inactivated by a single mutation within the DNA-binding domain resulting in a functionally impaired full-length protein (Soussi and Lozano, 2005; Goh et al, 2011).
We paid special attention to the gene agl1, not only because it is the only gene affected by a LoF mutation within the 200-kb region but also because it encodes an extracellular alpha-glucosidase involved in maltose utilization (Kato et al. 2013).
To ensure that this result was not caused by a suppressor mutation within the SCFTIR1 auxin system in the two clones we generated (Supplementary Figure 4), we rescued the mAID-Venus-ANAPC4 degradation with the mAID-nanobody.
