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The team is particularly intrigued by a mutation at position 226 of the E1 gene, which occurred in the fall of 2005, just before Chikungunya infections started soaring.
Interestingly, the (S,S -selective variantS,S -selectiveations at position 114 alone or at residues 114 and 116, whereas the (R,R)-selectivariantsnts are chavecterized by a modificationsosition 80 atone or two mutations at the 80 and 83 positions (Table 2).
Notably, this accumulation can be suppressed by a mutation at the H2A phosphoacceptor S129.
We are aware that this does not necessarily imply that OP is caused by a mutation at a single locus.
These data imply that in the majority of cases the HI phenotype is caused by a mutation at the hit locus; however, mutations occurring in other loci at lower frequencies (11% of the cases) may also result in host independence.
In this study, the exon-2 skipping of the nonfunctional transcript SV2 was, at least partly, accounted for by a mutation at the splice site of intron 1, IVS2-1G>T, as indicated by mini gene assay.
Similar(45)
Thr189 is usually autophosphorylated, but this modification can be abrogated by introducing a mutation at this site [9].
Box 4. Genetic suppression In genetic suppression, a mutant phenotype is reversed by the effects of a mutation at a locus distinct to that of the original mutation.
In genetic suppression, a mutant phenotype is reversed by the effects of a mutation at a locus distinct to that of the original mutation.
This was later explained by the presence of a mutation at codon 482 in the mRNA sequence of BCRP, with replacement of the wild-type arginine by threonine or glycine (R482T or R482G) [97], [97].
Thus, in many cases the impact of multiple mutations can be calculated by first determining the effects of a mutation at a single position and subsequently summing these effects using the quasi-additive assumption.
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CEO of Professional Science Editing for Scientists @ prosciediting.com