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For both virus infections there was an increase followed by a modest decrease between 4 and 12 h post infection as observed previously in a study of one step growth kinetics of HIV-1 [34].
Esmolol infusion was followed by a modest decrease in MAP during surgery in comparison with baseline (P < 0.01), whereas no change versus baseline occurred in the other two groups.
Treatment of rat adjuvant arthritis with SP600125, an inhibitor that affects kinase activity of both JNK1 and JNK2, was followed by a modest decrease of inflammation and paw swelling and an impressive inhibition of radiographic damage [ 21].
This is supported by a recent study in which a weak and insignificant expression of PEPCK messenger RNA was reported in C57BL/6 mice immediately after 60 min of exercise at 14 m/min−1, which was accompanied by a modest decrease in liver glycogen content.
A reduction of 12-26% in myocardial [C]HED retention is paralleled by a modest decrease in relative cardiac NET expression and an increase in plasma and cardiac NE content at 8 weeks of diabetes with no change in sympathetic nerve density.
Several population-based studies in England, Northern Europe, Canada, and the US have observed an increase in hospital admission and operation rate for gallstone diseases since the 1950s, followed by a modest decrease in the 1980s and a substantial increase in the 1990s after the introduction of laparoscopic cholecystectomy [ 17- 20].
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Similarly, when TARBP2 levels were reduced by siRNA treatment there was a modest decrease in Dicer protein.
Pre-let-7e (group I) was not strongly affected by TUT7/4/2, yet we detected a modest decrease in uridylation and an accumulation of trimmed pre-let-7e (Fig 4D, left).
However we cannot exclude that also K194 could be acetylated by p300 since we observed a modest decrease in the level of acetylation of the p63-K194R mutant peptide compared with the wild-type peptide.
Indeed, detailed analysis of kanamycin's activity against nonreplicating M. tuberculosis by a CFU assay showed a modest decrease of CFU with increased drug concentrations that did not achieve the 2 to 3 log10 kill predicted by the CARA (see Fig. S3b in the supplemental material).
As a result, a modest decrease of proliferation induced by milatuzumab by using CFSE labeling could be detected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com