Expression of these UPR components showed a moderate induction.
We observed a moderate induction of phosphorylated STAT3 in PL10 and PL12 after IL-6 treatment with little or no induction in an unmethylated cell line (Panc-1).
On our microarrays we did observe a moderate induction (1.7-fold) in STC2 transcript levels after induction with oestrogen for 6 hours, essentially parallel to STC1 (Fig. 1).
Most of the PEX genes showed a moderate induction upon the shift to methanol (up to 4-fold; Table 1).
We also saw a moderate induction of Atg5 in NA-treated MCF-7 and MDA-MB-231 cells.
We observed a very moderate induction of differentiation in control cells, when treated with cytarabine.
A moderate apoptosis induction by CQ is massively augmented in cells under starvation.
The moderate induction by hypoxia in these experiments was further enhanced by IL-6.
36 A robust early phase of ERK1/2 signaling followed by a moderate sustained phase leads to transient induction of p21 and accumulation of cyclin D1, allowing G1 progression.
Furthermore, SlDXS2 is moderately induced by wounding in the cultivar Moneymaker [ 49], which correlates with the observed moderate induction of SlDXS2 by JA (~1.6-fold, Table 4).
