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This situation is illustrated by a modelling study performed by the Health Technology Board of Scotland.
It may also lead to more false-positive results as has been pointed out by a modelling study that assumes that test performance does not change during repeat testing [ 13].
This was recently corroborated by a modelling study [44 ] and, in fact, the coffee protein, like its Arabidopsis relative, was predicted to present a single transmembrane domain, suggesting a similar, but atypical topology of the two counterparts.
This is supported by a modelling study that suggested that the efficacy of sentinel animals in predicting human cases is dependent on the vector infection rate, the biting rate on the target animals and the number of sentinel animals used, so it cannot be assumed that the success of sentinel chickens in one situation will translate to another [ 20].
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A modelling study by Marshall and Rouse 38 found similar results to our own.
Intriguingly, in a modelling study by Kaneko, fundamentally different results were found [ 57, 58].
However all three possibilities should be considered in a modelling study by different scenarios based on adequate meta-analyses.
A modelling study by Gemmell et al estimated the population impact of strategies to prevent coronary heart disease in England using aggregate data.
Similarly, a modelling study by Baskett et al. (2005) suggests that marine reserves can indeed help to counter maladaptive fisheries-induced evolutionary changes in traits such as age and size at maturation.
A modelling study by the manufacturer considering the epidemiological impact of Bexsero also found that maximal case reduction was achieved through routine infant vaccination in the short term and adolescent vaccination in the long term, assuming a high vaccine efficacy against carriage (67%).
A modelling study commissioned by the Department of Health suggested that stepwise screening and subsequent interventions would prevent 4000 new cases of diabetes each year.
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